Article

KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damage

2026-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Chemoresistance remains a major obstacle to effective cancer treatment, often driven by enhanced DNA repair mechanisms that enable tumor cells to withstand genotoxic therapies. One such pathway involves the atypical DNA damage repair complex ALKBH3–ASCC, activated by the E3 ligase RNF113A in response to alkylation damage. We previously showed that SMYD3-dependent methylation of RNF113A stimulate...

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Literature Corpus work: 1b235c14-dd35-5913-9aea-a77a25eb5fa6
DOI: 10.64898/2026.01.03.697470

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