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Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets

25 Jun 2020

Abstract excerpt

BACKGROUND: Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response remain unclear. We performed an epigenome-wide study of 66 human SCLC cell lines using the Illumina Infinium MethylationEPIC BeadChip array. Correlations of SCLC DNA methylation and gene...

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PMID: 32586373
DOI: 10.1186/s13148-020-00876-8

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