Article

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

2022-04-22

Abstract excerpt

<h4>Summary</h4> Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that DDX4, a germline factor and RNA helicase conserved in all multicellular organisms, contributes to epithelial mesenchyme transition (EMT)-like features and cisplatin resistance in small cell lung cancer (SCLC) cells. DDX4 depletion in H69AR and...

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Literature Corpus work: addbd125-c553-5e0f-9e1f-b7062dd598c0
DOI: 10.1101/2022.04.22.489111

Open publication

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