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METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

7 Jan 2022

Abstract excerpt

Abstract Background N6-methyladenosine (m 6 A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear. Here, we explored the biological function and underlying mechanism of methyltransferase-like 3 (METTL3), the main catalyst of m 6 A, in LUAD progression. Methods The expression of m 6 A, METTL3, YTHDF1 and SLC7A11 were detected...

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Share to Cancer-related gene regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34996469
DOI: 10.1186/s12935-021-02433-6

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