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Article

Clinical significance of tumor mutation burden and DNA damage repair in advanced stage non-small cell lung cancer patients.

European review for medical and pharmacological sciences - 1 Jul 2020

Zhang H, Deng Y-M, Chen Z-C, Tang Y-C, Yang S, Zhang S-D, Liang J-M, Wang Y-G, Wu X, Zhang R-W, Feng W-N

Abstract excerpt

OBJECTIVE: This study aimed to investigate the impact of tumor mutational burden (TMB) and DNA damage repair (DDR) gene alteration on overall survival (OS) in advanced non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: A DNA library of cancer cells from 67 NSCLC patients in stages III-IV was constructed for next-generation sequencing (NGS). Geneseeq422 probes were used for hybridization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32744692
DOI: 10.26355/eurrev_202007_22267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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