Article

Mitochondrial DNA Release Activates cGAS-STING Signaling in Membranous Nephropathy: Therapeutic Attenuation by Pathway Inhibition

2026-02-10

Abstract excerpt

<title>Abstract</title> <p>Background Membranous nephropathy (MN) is a chronic kidney disease mediated by autoimmunity, but its molecular mechanisms remain incompletely understood. Studies have suggested that mitochondrial damage leading to mitochondrial DNA (mtDNA) leakage may contribute to the development of autoimmune diseases by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (ST...

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Literature Corpus work: 1afa254e-14d8-58f8-b52e-dca1c062b172
DOI: 10.21203/rs.3.rs-8685107/v1

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