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Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway

6 Mar 2024

Abstract excerpt

ABSTRACT: Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease. However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive. The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have...

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PMID: 38445370
DOI: 10.1097/cm9.0000000000003022

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