Article

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

2024-05-10

Abstract excerpt

<title>Abstract</title> <p>Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the control of growth, differentiation, and apoptosis. In this study, we found that PKC-δ was highly upregulated in human biopsy samples and mouse kidneys with fibrosis. Rottlerin, a PKC...

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Literature Corpus work: 02af92e7-5d40-5a9d-8f99-01cc9580d3f8
DOI: 10.21203/rs.3.rs-4249479/v1

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Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in miceDOI 10.21203/rs.3.rs-4249479/v1Read

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