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Article

Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease

26 Nov 2024

Abstract excerpt

Diabetic kidney disease (DKD) is the leading cause of chronic renal pathology. Understanding the molecular underpinnings of DKD is critical to designing tailored therapeutic approaches. Here, we focused on sex differences and the contribution of aging toward the progression of DKD. To explore these questions, we utilized young (12 weeks old) and aged (approximately 50 weeks old) type 2 diabetic nephropathy (T2DN)...

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PMID: 39589791
DOI: 10.1172/jci.insight.174126

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