Article
A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes.
American journal of human genetics - 3 Dec 2020
Torres Jason M, Abdalla Moustafa, Payne Anthony, Fernandez-Tajes Juan, Thurner Matthias, Nylander Vibe, Gloyn Anna L, Mahajan Anubha, McCarthy Mark I
Abstract excerpt
Resolving the molecular processes that mediate genetic risk remains a challenge because most disease-associated variants are non-coding and functional characterization of these signals requires knowledge of the specific tissues and cell-types in which they operate. To address this challenge, we developed a framework for integrating tissue-specific gene expression and epigenomic maps to obtain "tissue-of-action"...
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