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Article

Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing.

The Journal of biological chemistry - 1 Feb 2026

Yang Ran, Hunker Olivia, Kim Jenna, Bleichert Franziska

Abstract excerpt

Meier-Gorlin syndrome (MGS) is a form of primordial dwarfism linked to mutations in DNA replication initiation factors. Many MGS variants affect proteins required for the first step of replication initiation-the licensing of replication origins-during which the origin recognition complex (ORC), CDC6, and CDT1 cooperatively load MCM2-7 complexes onto DNA as an MCM double hexamer. The specific impacts of MGS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41448435
DOI: 10.1016/j.jbc.2025.111100
PMCID: PMC12830165

Genes

CDC6
CDT1
MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing.PMID 41448435Read ↗

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