Article

Functional Role of Small Extrachromosomal Circular DNA in Colorectal Cancer

2025-08-02

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) are circular DNA molecules that originate from chromosomal DNA but exist independently. While large eccDNA (ecDNA) contributes to tumorigenesis, the role of smaller eccDNA (<100,000 base pairs) in cancer remains unclear. Our analysis of 25 colorectal cancer (CRC) tumors and adjacent non-tumorous tissues revealed that eccDNA is significantly more abundant in tumor tissues, cor...

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Literature Corpus work: 1ac9bb81-6bd0-5afd-a5a0-bbe5ee510315
DOI: 10.1101/2025.08.01.668183

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