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Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer

1 Apr 2025

Abstract excerpt

BACKGROUND: Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. METHODS: We conducted a Circle-Seq analysis on clinical samples at different stages of colorectal cancer progression to examine the dynamic changes of eccDNA during the progression of...

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PMID: 40165080
DOI: 10.1186/s10020-025-01164-y

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