Article

Tim-3 Promotes Early Differentiation of Tbet <sup>+</sup> Effector T Cells During Acute Viral Infection

2025-07-11

Abstract excerpt

The transmembrane protein Tim-3 has received significant attention in recent years as a possible immunotherapy target. This is due to its robust expression on dysfunctional, exhausted, T cells found in the settings of cancer and chronic infection and biochemical evidence suggesting an inhibitory function of Tim-3. However, numerous clinical trials of putative Tim-3 blocking antibodies have yielded modest benefits,...

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Literature Corpus work: 1ac5d784-4a4c-585e-ac09-d0513c0b6436
DOI: 10.1101/2025.07.08.663709

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