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Article

LAG-3: from molecular functions to clinical applications

1 Sept 2020

Abstract excerpt

To prevent the destruction of tissues owing to excessive and/or inappropriate immune responses, immune cells are under strict check by various regulatory mechanisms at multiple points. Inhibitory coreceptors, including programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4), serve as critical checkpoints in restricting immune responses against self-tissues and tumor cells. Immune checkpoint...

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PMID: 32929051
DOI: 10.1136/jitc-2020-001014

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