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Article

TIM-3 Regulates Distinct Functions in Macrophages

13 Jun 2016

Abstract excerpt

The transmembrane protein TIM-3 is a type I protein expressed by sub-types of lymphoid cells, such as lymphocytes Th1, Th17, Tc1, NK, as well as in myeloid cells. Scientific evidence indicates that this molecule acts as a negative regulator of T lymphocyte activation and that its expression is modified in viral infections or autoimmune diseases. In addition to evidence from lymphoid cells, the function of TIM-3...

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PMID: 27379093
DOI: 10.3389/fimmu.2016.00229

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