Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.

doi:10.1084/jem.20081398

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.

The Journal of experimental medicine - 24 Nov 2008

Jones R Brad, Ndhlovu Lishomwa C, Barbour Jason D, Sheth Prameet M, Jha Aashish R, Long Brian R, Wong Jessica C, Satkunarajah Malathy, Schweneker Marc, Chapman Joan M, Gyenes Gabor, Vali Bahareh, Hyrcza Martin D, Yue Feng Yun, Kovacs Colin, Sassi Aref, Loutfy Mona, Halpenny Roberta, Persad Desmond, Spotts Gerald, Hecht Frederick M, Chun Tae-Wook, McCune Joseph M, Kaul Rupert, Rini James M, Nixon Douglas F, Ostrowski Mario A

Abstract excerpt

Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3. The frequency of this population was increased in HIV-1-i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA3 Transcription Factor

Share to Hepatitis A Virus Cellular Receptor 2

Share to p38 Mitogen-Activated Protein Kinases

Share to Programmed Cell Death 1 Receptor

Share to STAT5 Transcription Factor

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19001139
DOI: 10.1084/jem.20081398
PMCID: PMC2585847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19001139-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.PMID 19001139Read ↗

TIMs: central regulators of immune responsesSemantic proximity Read ↗

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T CellsSemantic proximity Read ↗

Tim-3 Promotes Early Differentiation of Tbet <sup>+</sup> Effector T Cells During Acute Viral InfectionSemantic proximity Read ↗

Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector FunctionsSemantic proximity Read ↗

Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion.Semantic proximity Read ↗

Immune regulation by Tim-3Semantic proximity Read ↗

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicitySemantic proximity Read ↗

TIM-3 Regulates Distinct Functions in MacrophagesSemantic proximity Read ↗

Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection.Semantic proximity Read ↗

T Cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-Derived Mononuclear Cells in Multiple SclerosisSemantic proximity Read ↗

Protective HIV-specific CD8+ T cells evade Treg cell suppression.Semantic proximity Read ↗

Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.