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Article

TIMs: central regulators of immune responses

17 Nov 2008

Abstract excerpt

Exhaustion of T cell responses during chronic viral infections has been observed in both mouse and man and has been attributed to up-regulation of PD-1 on the surface of exhausted T cells. In patients with chronic human HIV infection, T cell exhaustion leads to opportunistic infections associated with AIDS. However, not all the exhausted T cells express PD-1, suggesting that other molecules may be involved in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19015312
DOI: 10.1084/jem.20082429

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Related research

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TIMs: central regulators of immune responsesPMID 19015312Read ↗

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Tim-3 Promotes Early Differentiation of Tbet <sup>+</sup> Effector T Cells During Acute Viral InfectionSemantic proximity Read ↗

Coinhibitory receptors and CD8 T cell exhaustion in chronic infectionsSemantic proximity Read ↗

The costimulatory role of TIM moleculesSemantic proximity Read ↗

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T CellsSemantic proximity Read ↗

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Semantic proximity Read ↗

Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19.Semantic proximity Read ↗

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Roles, function and relevance of LAG3 in HIV infectionSemantic proximity Read ↗

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