Article

Tim-3 drives tissue Treg effector function to promote neonatal immune tolerance and tumor-induced immune suppression

2020-07-17

Abstract excerpt

<title>Abstract</title> <p>Tissue regulatory T cells (Treg) are a key player in preventing immune pathology and shaping the immune suppressive tumor microenvironment (TME). The signaling molecules that uniquely regulate tissue Treg are not well understood. Here, we show that Tim-3 was predominantly expressed in Treg cells in both normal and tumor tissues. Notably, Tim-3 deficiency in Tregs led to the development...

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Identifiers and source

Literature Corpus work: 69ec8f68-2bde-506e-9e85-710db4685f05
DOI: 10.21203/rs.3.rs-38445/v1

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