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Article

Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination.

Science translational medicine - 8 Apr 2015

Fuertes Marraco Silvia A, Soneson Charlotte, Cagnon Laurène, Gannon Philippe O, Allard Mathilde, Abed Maillard Samia, Montandon Nicole, Rufer Nathalie, Waldvogel Sophie, Delorenzi Mauro, Speiser Daniel E

Abstract excerpt

Efficient and persisting immune memory is essential for long-term protection from infectious and malignant diseases. The yellow fever (YF) vaccine is a live attenuated virus that mediates lifelong protection, with recent studies showing that the CD8(+) T cell response is particularly robust. Yet, limited data exist regarding the long-term CD8(+) T cell response, with no studies beyond 5 years after vaccination....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25855494
DOI: 10.1126/scitranslmed.aaa3700

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