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Article

Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3.

European journal of immunology - 1 Jul 2021

Zhao Yanran, Cai Curtis, Samir Jerome, Palgen Jean-Louis, Keoshkerian Elizabeth, Li Hui, Bull Rowena A, Luciani Fabio, An Hongyan, Lloyd Andrew R

Abstract excerpt

Long-lived T-memory stem cells (TSCM ) are key to both naturally occurring and vaccine-conferred protection against infection. These cells are characterized by the CD45RA+ CCR7+ CD95+ phenotype. Significant heterogeneity within the TSCM population is recognized, but distinguishing surface markers and functional characterization of potential subsets are lacking. Human CD8 TSCM subsets were identified in healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33844287
DOI: 10.1002/eji.202049057

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