Article

White matter changes in the perforant path in patients with amyotrophic lateral sclerosis

2019-02-12

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive and incurable motor neuron disease. Some ALS patients are affected by a level of cognitive or behavioural decline that meets the criteria for frontotemporal dementia (FTD). ALS and FTD share genetic and pathological features; for example, the deposition of phosphorylated 43 kDa TAR DNA-binding protein (pTDP-43) in the brain. Spreading of pTDP-43 pathology in ALS...

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Literature Corpus work: 1aaa232b-db89-5a86-8aa7-6762a33a94e9
DOI: 10.1101/547588

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