Article

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD

2020-05-25

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative diseases that are increasingly understood to have long prodromal periods. Investigation of these early stages promises to yield valuable biomarkers of disease and will be key to understanding mechanisms underlying the genesis of ALS-FTD. Here, we use in vivo magnetic resonance imaging (MRI), histology and compu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94a0e8e5-6b09-5b1d-bc6a-3def18d3620f
DOI: 10.1101/2020.05.24.107177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTDDOI 10.1101/2020.05.24.107177Read

Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AβPP/PS1 Mice Both in vivo and ex vivo.Semantic proximity Read

Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits.Semantic proximity Read

The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy.Semantic proximity Read

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s diseaseSemantic proximity Read

TDP-43 expression in the cytoplasm leads to early synaptic and mitochondrial abnormalities in an inducible mouse model of ALS/FTDSemantic proximity Read

White matter changes in the perforant path in patients with amyotrophic lateral sclerosisSemantic proximity Read

Dissecting the neuronal vulnerability underpinning Alpers' syndrome: a clinical and neuropathological study.Semantic proximity Read

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse ModelsSemantic proximity Read

Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s diseaseSemantic proximity Read