Article
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse.
PloS one - 1 Jan 2012
Ip Chi Wang, Kroner Antje, Groh Janos, Huber Marianne, Klein Dennis, Spahn Irene, Diem Ricarda, Williams Sarah K, Nave Klaus-Armin, Edgar Julia M, Martini Rudolf
Abstract excerpt
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport. Using fluorogold stereotactically injected into the colliculus superior, we found that PLP overexpression in oligodendrocytes led to significantly reduced retrograde axonal transport in retina ganglion cell...
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