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Article

Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5+/- mice.

International journal of biological sciences - 1 Jan 2021

Zhang Rui, Chen Yongkang, Wang Xinxin, Tian Haiyan, Liu Han, Xiang Zhi, Qi Dan, Huang Jason H, Wu Erxi, Ding Xuebing, Wang Xuejing

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by phosphorylated TDP-43 (pTDP-43)-positive inclusions in neurons and glial cells. However, the pathogenic mechanism that underlies ALS remains largely unknown. To investigate the effects of autophagy deficiency in the formation and spreading of pathological TDP-43 along corticospinal tract axons, TDP-43 preformed...

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PMID: 33613100
DOI: 10.7150/ijbs.53872
PMCID: PMC7893595

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