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Article

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.

Annals of neurology - 1 Jul 2013

Brettschneider Johannes, Del Tredici Kelly, Toledo Jon B, Robinson John L, Irwin David J, Grossman Murray, Suh EunRan, Van Deerlin Vivianna M, Wood Elisabeth M, Baek Young, Kwong Linda, Lee Edward B, Elman Lauren, McCluskey Leo, Fang Lubin, Feldengut Simone, Ludolph Albert C, Lee Virginia M-Y, Braak Heiko, Trojanowski John Q

Abstract excerpt

OBJECTIVE: To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages. METHODS: pTDP-43 immunohistochemistry was performed on 70 μm sections from ALS autopsy cases (N = 76) classified by clinical phenotype and genetic background. RESULTS: ALS cases with the lowest...

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Identifiers

PMID: 23686809
DOI: 10.1002/ana.23937
PMCID: PMC3785076

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