Article

Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

2024-02-12

Abstract excerpt

Boosting slow-wave activity (SWA) by modulating slow-waves through closed-loop auditory stimulation (CLAS) might provide a powerful nonpharmacological tool to investigate the link between sleep and neurodegeneration. Nevertheless, CLAS in this context was not yet explored. Here, we established mouse CLAS (mCLAS)-mediated SWA enhancement and explored its effects onto sleep deficits in neurodegeneration, by targetin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e48657f-81c2-53dc-95c6-33de4120a7f8
DOI: 10.1101/2024.02.12.579922

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegenerationDOI 10.1101/2024.02.12.579922Read

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegenerationSemantic proximity Read

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration.Semantic proximity Read

Sound-Enhanced Sleep Depth Reduces Traumatic Brain Injury Damage and Sequelae and Supports Microglial ResponseSemantic proximity Read

Multitaper Time-frequency Peak-based Longitudinal Sleep Analysis in 5XFAD Mouse ModelSemantic proximity Read

Early Loss of Deep Restorative Sleep and Auditory Stimulus Evoked 40-Hz activity of Hippocampal Parvalbumin Neurons in the APP/PS1 Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Natural age-related sleep-wake alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s diseaseSemantic proximity Read

Experience-dependent sharp-wave ripple deficits in an Alzheimer’s disease mouse modelSemantic proximity Read

Closed-loop auditory stimulation of sleep slow oscillations: basic principles and best practicesSemantic proximity Read

Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy.Semantic proximity Read

Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimer’s DiseaseSemantic proximity Read

Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging miceSemantic proximity Read

Sleep is bi-directionally modified by amyloid beta oligomersSemantic proximity Read