Article

Reduced REM sleep fast theta power suggests early circuit vulnerability in a GBA1 mouse model of prodromal synucleinopathy

2026-02-09

Abstract excerpt

<title>Abstract</title> <p>Sleep disturbance is a salient harbinger of synucleinopathies and is conspicuous in idiopathic REM sleep behaviour disorder. Variants in GBA1 confer substantial risk for iRBD and Parkinson’s disease, yet early electrophysiological correlates remain uncertain. We recorded 24‑h EEG/EMG in adult male D409V/WT GBA1 knock‑in and wild‑type mice. A priori, REM fast‑theta (8–10 Hz) relative pow...

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Literature Corpus work: 8a3cd2aa-56c6-5702-9984-896b1e08beee
DOI: 10.21203/rs.3.rs-7794342/v1

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