Article

REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging

2025-08-22

Abstract excerpt

Rapid Eye Movement (REM) sleep degrades with age, and more severely in Alzheimer’s disease (AD). REM sleep comprises about twenty percent of adult sleep, alternates between phasic and tonic periods, and includes delta waves (1-4Hz) in two forms: fast sawtooth waves and slower, NREM-like waves, whose expression dynamically varies across REM periods. Yet, the functional relevance of these REM sleep delta waves remai...

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Literature Corpus work: 416db8b9-1dd3-5436-8d68-0b49b81296ed
DOI: 10.1101/2025.08.18.670879

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