Article

Beta-cell Cre expression and reduced <i>Ins1</i> gene dosage protect mice from type 1 diabetes

2022-02-04

Abstract excerpt

A central goal of physiological research is the understanding of cell-specific roles of disease-associated genes. Cre-mediated recombineering is the tool of choice for cell type-specific analysis of gene function in pre-clinical models. In the type 1 diabetes research field, multiple lines of NOD mice have been engineered to express Cre recombinase in pancreatic β-cells using insulin promoter fragments, but tissue...

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Literature Corpus work: 1a991802-4938-5d64-bc3a-438e70bea4a4
DOI: 10.1101/2022.02.03.479027

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