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Article

Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.

Endocrinology - 1 Aug 2020

Mosleh Elham, Ou Kristy, Haemmerle Matthew W, Tembo Teguru, Yuhas Andrew, Carboneau Bethany A, Townsend Shannon E, Bosma Karin J, Gannon Maureen, O'Brien Richard M, Stoffers Doris A, Golson Maria L

Abstract excerpt

Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly specific for beta cells also displayed expression in other islet endocrine cells or in a subset of neurons in the brain. Several pancreas and endocrine Cre lines have experienced silencing or mosaicism over time. In addition, many Cre transgenic constructs were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32267917
DOI: 10.1210/endocr/bqaa054
PMCID: PMC7354059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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