Article

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

2019-10-29

Abstract excerpt

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes akin to human type 1 diabetes. For this reason, the NOD mouse has been the preeminent murine model for human type 1 diabetes research for several decades. However, humanized mouse models are highly sought after because t...

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Literature Corpus work: c88f697d-cd63-580e-9f5e-01a4554b1a27
DOI: 10.1101/823393

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