Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.

PLoS genetics - 1 Apr 2021

Chiyoda Hirohisa, Kume Masahiko, Del Castillo Carla Cadena, Kontani Kenji, Spang Anne, Katada Toshiaki, Fukuyama Masamitsu

Abstract excerpt

Spatiotemporal restriction of signaling plays a critical role in animal development and tissue homeostasis. All stem and progenitor cells in newly hatched C. elegans larvae are quiescent and capable of suspending their development until sufficient food is supplied. Here, we show that ptr-18, which encodes the evolutionarily conserved patched-related (PTR)/patched domain-containing (PTCHD) protein, temporally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Membrane

Share to Endocytosis

Share to Hedgehog Proteins

Share to Neural Stem Cells

Share to Patched Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 33872306
DOI: 10.1371/journal.pgen.1009457
PMCID: PMC8104386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.PMID 33872306Read ↗

The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix.Semantic proximity Read ↗

Patched regulates cell cycle and tissue architecture in C. elegans gonadSemantic proximity Read ↗

Development. Longing for ligand: hedgehog, patched, and cell death.Semantic proximity Read ↗

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Semantic proximity Read ↗

A Ubiquitin network safeguards cell identity by continuously degrading a stem-cell related translational machinerySemantic proximity Read ↗

The role of ciliary trafficking in Hedgehog receptor signalingSemantic proximity Read ↗

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathwaySemantic proximity Read ↗

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.Semantic proximity Read ↗

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.Semantic proximity Read ↗

Reduction of Derlin activity suppresses Notch-dependent tumours in the <i>C. elegans</i> germ lineSemantic proximity Read ↗

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.Semantic proximity Read ↗

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.