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Article

A neurodegenerative disease affecting synaptic connections in Drosophila mutant for the tumor suppressor morphogen Patched.

Developmental biology - 1 Oct 2009

Gazi Michal, Shyamala Baragur V, Bhat Krishna Moorthi

Abstract excerpt

The tumor suppressor morphogen, Patched (Ptc), has an extensive homology to the Niemann-Pick-C 1 (NPC1) protein. The NPC disease is a paediatric, progressive and fatal neurodegenerative disorder thought to be due to an abnormal accumulation of cholesterol in neurons. Here, we report that patched mutant adults develop a progressive neurodegenerative disease and their brain contains membranous and lamellar...

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Identifiers

PMID: 19635474
DOI: 10.1016/j.ydbio.2009.07.024
PMCID: PMC2760493

Genes

NPC1

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A neurodegenerative disease affecting synaptic connections in Drosophila mutant for the tumor suppressor morphogen Patched.PMID 19635474Read ↗

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