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Article

Forward genetics identifies cuticle and regulatory genes underlying cellular boundary integrity in C. elegans.

G3 (Bethesda, Md.) - 3 Jun 2026

Radović Uroš, Henricsson Marcus, Borén Jan, Pilon Marc

Abstract excerpt

In C. elegans, the epidermis and its overlying extracellular matrix form a primary protective barrier, functioning as the first line of defense against environmental factors. To properly develop those cellular boundaries, a tightly controlled interaction of many molecules and pathways is needed. Mutant alleles of paqr-2 and iglr-2 (lipid homeostasis), dpy-21 (membrane trafficking), and sma-1 (actin-binding...

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Identifiers

PMID: 42018738
DOI: 10.1093/g3journal/jkag070
PMCID: PMC13232528

Genes

PTCHD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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