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Article

Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye.

Investigative ophthalmology & visual science - 17 Nov 2011

Bibliowicz Jonathan, Gross Jeffrey M

Abstract excerpt

PURPOSE: Patched is a well-studied tumor suppressor and negative regulator of the Hedgehog (Hh) pathway. Earlier work in this laboratory has shown that embryonic zebrafish patched2 (ptc2) mutant retinas possess an expanded ciliary marginal zone (CMZ) and phenotypes similar to those in human patients with basal cell naevus syndrome (BCNS), a congenital disorder linked to mutations in the human PTCH gene. This...

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Identifiers

PMID: 22003118
DOI: 10.1167/iovs.11-8033
PMCID: PMC3231842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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