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The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix.

Genetics - 5 Nov 2021

Cohen Jennifer D, Cadena Del Castillo Carla E, Serra Nicholas D, Kaech Andres, Spang Anne, Sundaram Meera V

Abstract excerpt

The Patched-related superfamily of transmembrane proteins can transport lipids or other hydrophobic molecules across cell membranes. While the Hedgehog receptor Patched has been intensively studied, much less is known about the biological roles of other Patched-related family members. Caenorhabditis elegans has a large number of Patched-related proteins, despite lacking a canonical Hedgehog pathway. Here, we show...

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Identifiers

PMID: 34740248
DOI: 10.1093/genetics/iyab132
PMCID: PMC8570789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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