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A Hallmark-Integrated, Agent-Based Framework for Intratumor Heterogeneity in Melanoma Evolution

2026-01-18

Abstract excerpt

Advances in multiregion sequencing have revealed extensive intratumor heterogeneity (ITH) - the presence of genetically distinct subclones within a single tumor. ITH profoundly influences tumor behavior, including well-accepted hall-marks of cancer such as sustained proliferation, resistance to apoptosis, and immune evasion, and the emergence of therapeutic resistance. In this work, we introduce a hallmark-integra...

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Literature Corpus work
1a24752d-8f4a-55f0-ab11-5f7506211f0a
DOI
10.64898/2026.01.16.699757
Open publication

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A Hallmark-Integrated, Agent-Based Framework for Intratumor Heterogeneity in Melanoma EvolutionDOI 10.64898/2026.01.16.699757
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