Cancer evolution simulation identifies possible principles underlying intratumor heterogeneity

Abstract excerpt

Cancer arises from accumulation of somatic mutations and accompanying evolutionary selection for growth advantage. During the evolutionary process, an ancestor clone branches into multiple clones, yielding intratumor heterogeneity. However, principles underlying intratumor heterogeneity have been poorly understood. Here, to explore the principles, we built a cellular automaton model, termed the BEP model, which ca...

Topics

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• Cancer Genomics and Diagnostics
• Evolution, Molecular
• Genetic Heterogeneity
• Lung Cancer Treatments and Mutations
• Mutation
• Neoplasms
• Pancreatic and Hepatic Oncology Research
• Phylogeny

Identifiers and source

Literature Corpus work

9589a12f-576e-5e48-95d6-af6c8d067958

DOI

10.1101/022806