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Article

Structure and mechanism of RNA ligase.

Structure (London, England : 1993) - 1 Feb 2004

Ho C Kiong, Wang Li Kai, Lima Christopher D, Shuman Stewart

Abstract excerpt

T4 RNA ligase 2 (Rnl2) exemplifies an RNA ligase family that includes the RNA editing ligases (RELs) of Trypanosoma and Leishmania. The Rnl2/REL enzymes are defined by essential signature residues and a unique C-terminal domain, which we show is essential for sealing of 3'-OH and 5'-PO4 RNA ends by Rnl2, but not for ligase adenylation or phosphodiester bond formation at a preadenylated AppRNA end. The N-terminal...

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Source

Identifiers

PMID: 14962393
DOI: 10.1016/j.str.2004.01.011

Genes

REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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