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Article

Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study.

Microbiology spectrum - 7 Apr 2026

He Wencong, Tan Yunhong, Song Zexuan, Bai Hua, Hu Peilei, Ou Xichao, Zhao Bing, Liu Xiangyi, Zhao Yanlin

Abstract excerpt

Transmission of rifampicin-resistant and multidrug-resistant tuberculosis (MDR/RR-TB) is a major driver of the global drug-resistant TB epidemic, yet the contribution of compensatory mutations to its spread remains uncertain. We analyzed 206 non-duplicate MDR/RR-TB isolates collected from five surveillance sites in Hunan Province, China, between 2013 and 2020 using whole-genome sequencing. Transmission clusters...

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Identifiers

PMID: 41773868
DOI: 10.1128/spectrum.02597-25
PMCID: PMC13055236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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