Inclusion of minor alleles improves catalogue-based prediction of fluoroquinolone resistance in<i>Mycobacterium tuberculosis</i>

Abstract excerpt

Abstract Objectives Fluoroquinolone resistance poses a threat to the successful treatment of tuberculosis. WGS, and the subsequent detection of catalogued resistance-associated mutations, offers an attractive solution to fluoroquinolone susceptibility testing but sensitivities are often less than 90%. We hypothesize that this is partly because the bioinformatic pipelines used usually mask the recognition of minor...

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