Article

Parkin deficiency perturbs striatal circuit dynamics

2019-05-13

Abstract excerpt

Loss-of-function mutations in the parkin-encoding PARK2 gene cause young-onset, autosomal recessive Parkinson’s disease (PD). Here, we investigated how parkin mutations affect cortico-basal ganglia circuit dynamics and cell-type-specific functional connectivity by recording simultaneously from motor cortex, striatum and globus pallidus (GP) in anesthetized parkin-mutant mice. While ongoing activity of presumed str...

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Literature Corpus work: 19f6eb39-1970-5cdf-9c41-da8cf7804bdf
DOI: 10.1101/636142

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