Article

Single-neuron bursts encode pathological oscillations in Parkinson’s disease and essential tremor

2022-04-07

Abstract excerpt

Deep brain stimulation procedures offer an invaluable opportunity to study disease through intracranial recordings from awake patients. Herein, we address the relationship between singleneuron and aggregate-level (local field potential; LFP) activities in the subthalamic nucleus (STN) and thalamic ventral intermediate nucleus (Vim) of patients with Parkinson’s disease (n=19) and essential tremor (n=16), respective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e77d7422-f4a9-5818-a2b4-86d6dd79bcac
DOI: 10.1101/2022.04.05.486956

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-neuron bursts encode pathological oscillations in Parkinson’s disease and essential tremorDOI 10.1101/2022.04.05.486956Read

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleusSemantic proximity Read

Synaptic changes in pallidostriatal circuits observed in parkinsonian model triggers abnormal beta synchrony with accurate spatio-temporal properties across the basal gangliaSemantic proximity Read

Autonomous oscillations and phase-locking in a biophysically detailed model of the STN-GPe networkSemantic proximity Read

Pathological cortico-STN beta coupling in Parkinson’s disease is confined to beta burstsSemantic proximity Read

Unsupervised Clustering Reveals Spatially Varying Single Neuronal Firing Patterns in the Subthalamic Nucleus of Patients with Parkinson’s DiseaseSemantic proximity Read

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson’s diseaseSemantic proximity Read

Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillationsSemantic proximity Read

Subthalamic low beta bursts differ in Parkinson's disease phenotypes.Semantic proximity Read

Sensorimotor processing in the basal ganglia leads to transient beta oscillations during behaviorSemantic proximity Read

Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different MovementsSemantic proximity Read

Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta bandSemantic proximity Read

Rapid Motor Fluctuations Reveal Short-Timescale Neurophysiological Biomarkers of Parkinson’s DiseaseSemantic proximity Read