Article

Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band

2022-10-10

Abstract excerpt

Motor symptoms of Parkinson’s Disease (PD) are associated with dopamine deficits and pathological oscillation of basal ganglia (BG) neurons in the β range ([12-30] Hz). However, how the dopamine depletion affects the oscillation dynamics of BG nuclei is still unclear. With a spiking neurons model, we here captured the features of BG nuclei interactions leading to oscillations in dopamine-depleted condition. We fo...

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Literature Corpus work: ab8a7614-aec8-5520-b364-608bb816c5de
DOI: 10.1101/2022.10.10.511532

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