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Article

Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations.

Cell reports - 2 May 2017

Zhong Ping, Hu Zhixing, Jiang Houbo, Yan Zhen, Feng Jian

Abstract excerpt

Locomotor symptoms in Parkinson's disease (PD) are accompanied by widespread oscillatory neuronal activities in basal ganglia. Here, we show that activation of dopamine D1-class receptors elicits a large rhythmic bursting of spontaneous excitatory postsynaptic currents (sEPSCs) in midbrain neurons differentiated from induced pluripotent stem cells (iPSCs) of PD patients with parkin mutations, but not normal...

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Identifiers

PMID: 28467897
DOI: 10.1016/j.celrep.2017.04.023
PMCID: PMC5492970

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