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Article

Altered Information Processing in the Prefrontal Cortex of Huntington's Disease Mouse Models

3 Sept 2008

Abstract excerpt

Understanding cortical information processing in Huntington's disease (HD), a genetic neurological disorder characterized by prominent motor and cognitive abnormalities, is key to understanding the mechanisms underlying the HD behavioral phenotype. We recorded extracellular spike activity in two symptomatic, freely behaving mouse models: R6/2 transgenics, which are based on a CBA x C57BL/6 background and show...

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PMID: 18768691
DOI: 10.1523/jneurosci.2804-08.2008

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