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Article

Dysregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease.

Journal of neurophysiology - 1 Oct 2008

Miller Benjamin R, Walker Adam G, Shah Anand S, Barton Scott J, Rebec George V

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant condition that compromises behavioral output. Dysfunction of medium spiny neurons (MSNs), which are the sole output system of the striatum, is thought to underlie HD pathophysiology. What is not known is how HD alters MSN information processing during behavior, which likely drives the HD behavioral phenotype. We recorded from populations of MSNs in two freely...

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Identifiers

PMID: 18667541
DOI: 10.1152/jn.90606.2008
PMCID: PMC2576201

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MSN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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