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Article

TARDBP gene mutations in south Italian patients with amyotrophic lateral sclerosis

19 Oct 2010

Abstract excerpt

Neuronal synchronization in basal ganglia circuits plays a key role in the encoding of movement, procedural memory storage and habit formation. Striatal dopamine (DA) depletion during Parkinsonism causes abnormal synchronization in corticobasal ganglia loops resulting in motor dysfunction. However, the dynamics of the striatal microcircuit underlying abnormal synchronization in Parkinsonism is poorly understood....

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Identifiers

PMID: 20959352
DOI: 10.1136/jnnp.2009.198309

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