Article

Dopamine Depletion Drives Whole-Brain Oscillatory Disruptions via Cortico–Subcortical Resonance: A Multiscale Model of Parkinson’s Disease in Mice

2026-05-18

Abstract excerpt

Parkinson’s disease is defined by dopaminergic neuron loss in the substantia nigra, yet its hallmark, exaggerated beta-band synchrony, pervades motor cortex, thalamus, and cerebellum, implicating network dynamics far beyond any single circuit. How focal subcortical dopamine depletion translates into brain-wide oscillatory pathology remains unresolved. We use a connectome-constrained multiscale model of the mouse b...

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Literature Corpus work: b1b8b281-ee2b-5fa6-8ed1-4a636a4e166f
DOI: 10.64898/2026.05.15.725133

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